Accelerated Particle Swarm Optimization for Photovoltaic Maximum Power Point Tracking under Partial Shading Conditions

This paper presents an accelerated particle swarm optimization (PSO)-based maximum power point tracking (MPPT) algorithm to track global maximum power point (MPP) of photovoltaic (PV) generation under partial shading conditions. Conventional PSO-based MPPT algorithms have common weaknesses of a long convergence time to reach the global MPP and oscillations during the searching. The proposed algorithm includes a standard PSO and a perturb-and-observe algorithm as the accelerator. It has been experimentally tested and compared with conventional MPPT algorithms. Experimental results show that the proposed MPPT method is effective in terms of high reliability, fast dynamic response, and high accuracy in tracking the global MPP

Stability Study and Nonlinear Analysis of DC-DC Power Converters with Constant Power Loads at the Fast Timescale

Rapidly growing distributed renewable networks make an increasing demand on various types of power converters to feed different loads. Power converters with constant power load are one typical configuration that can degrade the stability of the power conversion system due to the negative impedance characteristic. This paper presents a nonlinear analysis method using the developed complete-cycle solution matrix method by transforming the original linear time-variant system into a summation of segmented linear time-invariant systems. Thus, the stability of the nonlinear system can be studied using a series of the corresponding state transition matrix and saltation matrix. As this derived matrix contains all the comprehensive information relating to the system’s stability, the influence of the constant power load to system’s fast-timescale stability in both continuous conduction mode and the discontinuous conduction mode can be fully investigated and analyzed. The phenomena of fast-timescale instability around switching frequency for power converters with a constant power load are observed and investigated numerically. Finally, experimental results have proven the analysis and verified the effectiveness of the developed method

An integrated switched reluctance motor drive topology with voltage-boosting and on-board charging capabilities for plug-in hybrid electric vehicles (PHEVs)

This paper presents a new topology of switched reluctance motor (SRM) drive for plug-in hybrid electric vehicles (PHEVs). Six operating modes can be achieved as a result. Three of those modes are applied for driving and the others for charging. During the driving mode, the topology can be converted to a four-level one. During the charging mode, two battery packs are charged in parallel with the boost circuit by the external AC source or generators. The main contributions of the proposed topology are as follows: 1) A four-level converter is formed by adopting different ways of connection (series or parallel) of the two battery packs (or the two capacitors), which can accelerate the excitation and demagnetization procedures of SRMs. Moreover, the topology contributes to decreasing the switching losses and extending the constant torque region to improve the drive performance as well. 2) The state of charge (SOC) of the two battery packs (or the voltages of two capacitors) can keep balance on their own by parallel operation of the two battery packs. Furthermore, a detailed comparison between two drive modes of the proposed topology and asymmetric half bridge inverters is undertaken with simulation and experimental studies, the results of which demonstrate the validity of the proposed topology

A switched reluctance motor torque ripple reduction strategy with deadbeat current control

This paper presents a switched reluctance motor (SRM) torque ripple reduction strategy with deadbeat current control. In this method, the SRM torque is indirectly controlled by the phase current. The deadbeat control method can predict the duty cycle of the switching signal for the next control period according to current error, and achieve an accurate current tracking. Thus, SRM torque control error can be reduced significantly. The feasibility and effectiveness of the proposed strategy have been verified in both simulation and experimental studies

A switched reluctance motor torque ripple reduction strategy with deadbeat current control and active thermal management

This paper presents a switched reluctance motor (SRM) torque ripple reduction strategy with deadbeat current control and active thermal management. In this method, the SRM torque is indirectly controlled by the phase current. A deadbeat current control method is used to improve the SRM phase current control accuracy, so that SRM torque control error can be reduced significantly. According to the online measurement of the power switching device temperature, the switching frequency will be reduced to prevent the SRM power converter from being damaged by over-temperature. The feasibility and effectiveness of the proposed strategy have been verified in both simulation and experimental studies

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma.

Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME). CD47 has been shown to mediate immune evasion, as the CD47-SIRPα axis prevents phagocytosis of tumor cells by macrophages and other myeloid cells. In this study, we established CD47 homozygous deletion (CD47-/-) in human and mouse GBM cells and investigated the impact of eliminating the "don't eat me" signal on tumor growth and tumor-TME interactions. CD47 knockout (KO) did not significantly alter tumor cell proliferation in vitro but significantly increased phagocytosis of tumor cells by macrophages in cocultures. Compared with CD47 wild-type xenografts, orthotopic xenografts derived from CD47-/- tumor cells grew significantly slower with enhanced tumor cell phagocytosis and increased recruitment of M2-like tumor-associated microglia/macrophages (TAM). CD47 KO increased tumor-associated extracellular matrix protein tenascin C (TNC) in xenografts, which was further examined in vitro. CD47 loss of function upregulated TNC expression in tumor cells via a Notch pathway-mediated mechanism. Depletion of TNC in tumor cells enhanced the growth of CD47-/- xenografts in vivo and decreased the number of TAM. TNC knockdown also inhibited phagocytosis of CD47-/- tumor cells in cocultures. Furthermore, TNC stimulated release of proinflammatory factors including TNFα via a Toll-like receptor 4 and STAT3-dependent mechanism in human macrophage cells. These results reveal a vital role for TNC in immunomodulation in brain tumor biology and demonstrate the prominence of the TME extracellular matrix in affecting the antitumor function of brain innate immune cells. SIGNIFICANCE: These findings link TNC to CD47-driven phagocytosis and demonstrate that TNC affects the antitumor function of brain TAM, facilitating the development of novel innate immune system-based therapies for brain tumors

CRISPR/Cas9‐mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse

The X‐linked genetic bleeding disorder caused by deficiency of coagulator factor IX, hemophilia B, is a disease ideally suited for gene therapy with genome editing technology. Here, we identify a family with hemophilia B carrying a novel mutation, Y371D, in the human F9 gene. The CRISPR/Cas9 system was used to generate distinct genetically modified mouse models and confirmed that the novel Y371D mutation resulted in a more severe hemophilia B phenotype than the previously identified Y371S mutation. To develop therapeutic strategies targeting this mutation, we subsequently compared naked DNA constructs versus adenoviral vectors to deliver Cas9 components targeting the F9 Y371D mutation in adult mice. After treatment, hemophilia B mice receiving naked DNA constructs exhibited correction of over 0.56% of F9 alleles in hepatocytes, which was sufficient to restore hemostasis. In contrast, the adenoviral delivery system resulted in a higher corrective efficiency but no therapeutic effects due to severe hepatic toxicity. Our studies suggest that CRISPR/Cas‐mediated in situ genome editing could be a feasible therapeutic strategy for human hereditary diseases, although an efficient and clinically relevant delivery system is required for further clinical studies

Optimised phase disposition pulse-width modulation strategy for hybrid-clamped multilevel inverters using switching state sequences

This study describes an optimised modulation strategy based on switching state sequences for the hybrid-clamped multilevel converter. Two key control variables defined as 'phase shift angle' and 'switching state change' for a five-level hybrid-clamped inverter are proposed to improve all switches' operation, and by changing their values, different control methods can be obtained for modulation optimisation purposes. Two example methods can solve the voltage imbalance problem of the dc-link capacitors and furthermore avoid two switches' simultaneous switching transitions and improve the inverter's performance as compared with the traditional phase disposition pulse-width modulation strategy. A 6 kW prototype inverter is developed and a range of simulation and experiments are carried out for validation. It is found that simulation and experimental results are in a good agreement and the proposed modulation strategy is verified in terms of low-order harmonic reduction